 | Jennifer Love Hewitt | ... | Melinda Gordon (107 episodes, 2005-2010) |
 | David Conrad | ... | Jim Clancy / ... (107 episodes, 2005-2010) |
 | Camryn Manheim | ... | Delia Banks (84 episodes, 2006-2010) |
 | Christoph Sanders | ... | Ned Banks (49 episodes, 2008-2010) |
 | Jamie Kennedy | ... | Eli James (45 episodes, 2008-2010) |
 | Jay Mohr | ... | Professor Rick Payne (33 episodes, 2006-2008) |
 | Patrick Weil | ... | Townsman / ... (28 episodes, 2009-2010) |
 | Aisha Tyler | ... | Andrea Marino (23 episodes, 2005-2006) |
 | Connor Gibbs | ... | Aiden Lucas (22 episodes, 2009-2010) |
 | Kenneth Mitchell | ... | Sam Lucas (15 episodes, 2008-2009) |
 | Ion Overman | ... | Det. Sam Blair (9 episodes, 2008-2010) |
 | Tyler Patrick Jones | ... | Ned Banks (8 episodes, 2006-2007) |
 | David Clennon | ... | Carl the Watcher (8 episodes, 2009-2010) |
 | Dariush Kashani | ... | Bobby Tooch (8 episodes, 2005-2009) |
 | Douglas Bierman | ... | Laughing Man (7 episodes, 2005-2006) |
 | Ignacio Serricchio | ... | Gabriel Lawrence (6 episodes, 2007-2008) |
 | Thomas F. Wilson | ... | Tim Flaherty (6 episodes, 2006-2008) |
 | June Squibb | ... | Grandma (6 episodes, 2005-2007) |
 | Grace Fulton | ... | Young Melinda (5 episodes, 2005-2007) |
 | Kurt Caceres | ... | Det. Carl Neely (5 episodes, 2008) |
 | Bruce Davison | ... | Josh Bedford (5 episodes, 2009-2010) |
 | Martin Donovan | ... | Tom Gordon (4 episodes, 2007-2008) |
 | Anne Archer | ... | Beth Gordon (4 episodes, 2006-2008) |
 | Wendy Worthington | ... | Admitting Nurse / ... (4 episodes, 2008-2009) |
 | Scott Rinker | ... | Reggie (4 episodes, 2006-2007) |
 | Rachel Shelley | ... | Kate Payne (4 episodes, 2006-2008) |
 | David Ramsey | ... | Will Bennett (4 episodes, 2005-2008) |
 | Afemo Omilami | ... | Archivist / ... (4 episodes, 2007-2008) |
 | Tim Guinee | ... | Charlie Filbert (3 episodes, 2006-2007) |
 | Omid Abtahi | ... | Justin Yates (3 episodes, 2007-2008) |
 | Corin Nemec | ... | Paul Eastman / ... (3 episodes, 2008) |
 | Jaclyn DeSantis | ... | Zoe Ramos (3 episodes, 2009) |
 | Dondre Whitfield | ... | Mitch Marino (3 episodes, 2005-2006) |
 | Kris Lemche | ... | Scott the Ghost (3 episodes, 2007) |
 | José Zúñiga | ... | Officer Luis Simon / ... (3 episodes, 2008-2010) |
 | Jordan Dang | ... | Dylan (3 episodes, 2005-2006) |
 | Rachel Cannon | ... | Amy Fields (3 episodes, 2006-2007) |
 | Madison Leisle | ... | Julia Miller (3 episodes, 2009) |
| Karen Maruyama | ... | Heather / ... (3 episodes, 2005-2008) |
 | Wayne Pére | ... | Dr. Epstein / ... (3 episodes, 2006-2007) |
 | Jennifer Weston | ... | Doctor / ... (3 episodes, 2008-2009) |
 | Margaret Cho | ... | Professor Avery Grant (3 episodes, 2010) |
 | Greg Cipes | ... | Jamey Barton (3 episodes, 2005-2007) |
 | Marcus Ashley | ... | Michael Ellis (3 episodes, 2005-2007) |
 | Bob Ross | ... | Townsmen (3 episodes, 2008-2009) |
 | Mohammad Kavianpour | ... | Audience Member / ... (3 episodes, 2009) |
 | Jon Seda | ... | John Gregory (2 episodes, 2006) |
 | Julian Sands | ... | Ethan Clark (2 episodes, 2007) |
 | Jon Polito | ... | Joe Grimaldi (2 episodes, 2005-2008) |
 | Wendy Phillips | ... | Diane Shields (2 episodes, 2005-2006) |
 | Chris Ellis | ... | Ghost Pilot (2 episodes, 2006) |
 | Michael Landes | ... | Kyle McCall / ... (2 episodes, 2006) |
 | Michael O'Keefe | ... | Dr. Byrd (2 episodes, 2009) |
| Rodney Scott | ... | Dan Clancy (2 episodes, 2005-2008) |
 | Fredric Lehne | ... | Charlie Banks (2 episodes, 2006-2007) |
 | Vivian Wu | ... | Prophet Ghost (2 episodes, 2007) |
 | Christine Estabrook | ... | Evelyn James (2 episodes, 2009) |
 | John Walcutt | ... | Wide Brim Man (2 episodes, 2006) |
 | Christine Baranski | ... | Faith Clancy (2 episodes, 2005) |
 | Robert LaSardo | ... | Crash Victim / ... (2 episodes, 2005) |
 | Chad Donella | ... | Randy Cooper (2 episodes, 2007) |
 | Brian White | ... | Officer Barrett (2 episodes, 2007) |
 | April Grace | ... | The Watcher (2 episodes, 2008-2009) |
 | John Paul Pitoc | ... | Jared (2 episodes, 2006-2007) |
 | Marco Sanchez | ... | Freddy Diaz (2 episodes, 2006) |
| Sarah Hunley | ... | Old Nurse / ... (2 episodes, 2005-2006) |
 | Kyle Chavarria | ... | Kristen Filbert (2 episodes, 2006-2007) |
 | Fay Hauser | ... | Doctor / ... (2 episodes, 2007-2009) |
 | Damien Leake | ... | Dr. Chiles (2 episodes, 2007-2008) |
| Mackenzie Hannigan | ... | Miles (2 episodes, 2006) |
 | Teri Polo | ... | Nikki (2 episodes, 2009) |
 | Graham Miller | ... | Guardian Spirit / ... (2 episodes, 2005-2006) |
 | Nate Torrence | ... | Waiter (2 episodes, 2005) |
 | John Eric Bentley | ... | Army Chaplain / ... (2 episodes, 2005-2006) |
 | Robert Chester Smith | ... | Funeral Director / ... (2 episodes, 2006-2007) |
 | Sarah Jaye | ... | Young Beth Gordon (2 episodes, 2007-2008) |
 | Kelli Kirkland | ... | Nurse / ... (2 episodes, 2009) |
 | Jeremy Shada | ... | Liam Fletcher (2 episodes, 2007) |
 | Mark Hapka | ... | Zach (2 episodes, 2007-2008) |
| Davide Schiavone | ... | Stefano Donato (2 episodes, 2007) |
 | Haley Pullos | ... | Young Melinda (2 episodes, 2008) |
 | Alex Daniels | ... | Driver / ... (2 episodes, 2007-2009) |
 | Alisa Vilena Gerstein | ... | Elena Petrova (2 episodes, 2007) |
 | Ricky Lewis Jr. | ... | Medic / ... (2 episodes, 2008-2009) |
 | Christian Camargo | ... | Brad Paulson (2 episodes, 2005) |
 | Jeffrey Hutchinson | ... | Father at Funeral / ... (2 episodes, 2005-2006) |
 | Irene White | ... | Cashier (2 episodes, 2007) |
 | Whitney Anderson | ... | Paige (2 episodes, 2005) |
 | Dave Hanson | ... | Gary (2 episodes, 2006) |
 | Mike Cochrane | ... | Carney / ... (2 episodes, 2006) |
| Juan Jose Dubon | ... | Ghost / ... (2 episodes, 2006) |
 | Daisy Eagan | ... | Drew Godfrey / ... (2 episodes, 2006) |
| Lou Glenn | ... | Bleeding Man (2 episodes, 2006) |
| Richie Rayfield | ... | Club Bartender / ... (2 episodes, 2006) |
 | Adam Thompson | ... | Young Jim (2 episodes, 2006) |
| William Ramos Jr. | ... | Cafe Patron / ... (2 episodes, 2007-2009) |
 | Jonas Neal | ... | Villager (2 episodes, 2007) |
 | Freedom | ... | Grandview Citizen (2 episodes, 2010) |
 | Joey King | ... | Cassidy (2 episodes, 2010) |
